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Mo1213 Efficacy and Safety of NNC0142-0002, a Novel Human Monoclonal Antibody Targeting NKG2D: a Randomized, Double-Blind, Single-Dose Phase 2 Trial in Patients With Crohn's Disease

โœ Scribed by Allez, Matthieu; Petryka, Robert; Skolnick, Brett E.; Wisniewska-Jarosinska, Maria A.


Book ID
122170880
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
189 KB
Volume
146
Category
Article
ISSN
0016-5085

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โœ C. Janneke van der Woude; Pieter Stokkers; Ad A. van Bodegraven; Gert Van Assche ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 274 KB ๐Ÿ‘ 2 views

Background: NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). Methods: A doub