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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase2b Study of Ustekinumab, a Human Monoclonal Antibody to IL-12/23p40, in Patients With Moderately to Severely Active Crohn's Disease: Results Through Week 22 From the Certifi Trial

✍ Scribed by William J. Sandborn; Christopher Gasink; Long-Long Gao; Marion Blank; Jewel Johanns; Cynthia Guzzo; Bruce E. Sands; Stephen B. Hanauer; Stephan R. Targan; Paul J. Rutgeerts; Subrata Ghosh; Willem de Villiers; Remo Panaccione; Gordon R. Greenberg; Stefan Schreiber; Simon Lichtiger; Brian G. Feagan


Book ID
119432290
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
145 KB
Volume
140
Category
Article
ISSN
0016-5085

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✍ C. Janneke van der Woude; Pieter Stokkers; Ad A. van Bodegraven; Gert Van Assche πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 274 KB πŸ‘ 2 views

Background: NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). Methods: A doub