A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase2b Study of Ustekinumab, a Human Monoclonal Antibody to IL-12/23p40, in Patients With Moderately to Severely Active Crohn's Disease: Results Through Week 22 From the Certifi Trial
β Scribed by William J. Sandborn; Christopher Gasink; Long-Long Gao; Marion Blank; Jewel Johanns; Cynthia Guzzo; Bruce E. Sands; Stephen B. Hanauer; Stephan R. Targan; Paul J. Rutgeerts; Subrata Ghosh; Willem de Villiers; Remo Panaccione; Gordon R. Greenberg; Stefan Schreiber; Simon Lichtiger; Brian G. Feagan
- Book ID
- 119432290
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 145 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0016-5085
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Background: NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). Methods: A doub