Matched-pair studies are often used in various applications such as in medical and biological research. In some experiments, blocks of size 2 exist naturally, examples include two eyes or two feet of a person. In these studies, the conditions within each blocks are assumed to be identical but differ
Mixture Models for Matched Pairs
β Scribed by Mary L. Lesperance and John D. Kalbfleisch
- Book ID
- 115057153
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 462 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0319-5724
- DOI
- 10.2307/3315823
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**Praise for the First Edition** "This is a superb text from which to teach categorical data analysis, at a variety of levels. . . [t]his book can be very highly recommended." β*Short Book Reviews* "Of great interest to potential readers is the variety of fields that are represented in the examp
2002] propose a mixture representation of the affected sib pair (ASP) likelihood ratio that allows inclusion of covariates. They correctly point out that the primary purpose of covariates in linkage models is to allow for locus heterogeneity. They show using simulations the considerable increase in
## Abstract To determine the genetic etiology of complex diseases, a common study design is to recruit affected sib/relative pairs (ASP/ARP) and evaluate their genomeβwide distribution of identical by descent (IBD) sharing using a set of highly polymorphic markers. Other attributes or environmental