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“Mixture models for linkage analysis of affected sibling pairs with covariates”

✍ Scribed by Jane M. Olson

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
74 KB
Volume
23
Category
Article
ISSN
0741-0395

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✦ Synopsis

2002] propose a mixture representation of the affected sib pair (ASP) likelihood ratio that allows inclusion of covariates. They correctly point out that the primary purpose of covariates in linkage models is to allow for locus heterogeneity. They show using simulations the considerable increase in power that can be attained when a covariate that measures heterogeneity is included in the linkage model. Their article joins an increasing body of work that proposes using additional phenotypic data not only to increase the power to detect linkage but also to help identify subsets of pairs with a common genetic architecture [

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