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Mitsunobu Approach to the Synthesis of Optically Active α,α-Disubstituted Amino Acids

✍ Scribed by Green, Jonathan E.; Bender, David M.; Jackson, Stona; O’Donnell, Martin J.; McCarthy, James R.


Book ID
118066015
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
121 KB
Volume
11
Category
Article
ISSN
1523-7060

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Practical synthesis of optically active
✍ Joëlle Viret; Jacqueline Gabard; André Collet 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 290 KB

Simple amino acids (1) can be converted in fair to good yield into hydrazino acids (3) of like configuration by using KOCI instead of NaOCl to promote the Shestakov rearrangement of the intermediate hydantoic acids (2). It was shown fifteen years ago by Karady et al.,' and later by Custafsson,' that