Mitoxantrone and cytosine arabinoside as treatment for acute myeloblastic leukemia in older patients
β Scribed by P. K. MacCallum; A. Z. S. Rohatiner; C. L. Davis; J. S. Whelan; A. M. Oza; J. Lim; S. Love; J. A. L. Amess; M. Leahy; R. K. Gupta; C. G. A. Price; T. A. Lister
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 530 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0939-5555
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Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete
Mitoxantrone (M) is a synthetic aminoanthraquinone with anti-leukemic activity in patients with daunorubicin (D) resistant acute leukemia. The Cancer and Leukemia Group B (CALGB) has undertaken a limited access pilot study in which M, 12 mg/m2, over 30 min, daily for 3 days, and cytosine arabinoside
Forty-four patients with a diagnosis of refractory or relapsed acute myelogenous leukemia received salvage chemotherapy with high-dose cytosine arabinosine 3 g/m2 intravenously over 2 hours every 12 hours for six doses and mitoxantrone 5 mg/m2 intravenously daily for 5 days. Overall 16 patients (36%