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Mitotic Catastrophe Results in Cell Death by Caspase-Dependentand Caspase-Independent Mechanisms

✍ Scribed by Mansilla, Sylvia; Priebe, Waldemar

Book ID: 115543430
Publisher: Landes Bioscience
Year: 2005
Tongue: English
Weight: 722 KB
Volume: 5
Category: Article
ISSN: 1538-4101
DOI: 10.4161/cc.5.1.2267

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Mitochondria play a critical role in cell death by releasing apoptogenic factors, such as cytochrome c and apoptosis-inducing factor (AIF), from the intermembrane space into the cytoplasm. Because mitochondrial dysfunction has been shown to be involved in several neurodegenerative diseases, mitochon