𝔖 Bobbio Scriptorium
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Mitomycin C extravasation injuries

✍ Scribed by Louis C. Argenta; Ernest K. Manders


Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
617 KB
Volume
51
Category
Article
ISSN
0008-543X

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πŸ“œ SIMILAR VOLUMES


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In a four-year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infus

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**Background**: Various agents have been implicated in causing tissue necrosis after intravenous infusions have extravasated. These include solutions of calcium, potassium, bicarbonate, hypertonic dextrose, cytotoxic drugs and antibiotics. Views on management of these injuries differ, and range from

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Two cases are presented which suggest that pyridoxine injected into a Mitomycin-C extravasation site may slow or prevent necrosis, and may decrease the pain associated with the chronic ulceration of extravasation.

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In a material consisting of approximately 6,000 injections of Adriamycin during a 2-year period, eleven moderate and five severe extravasation injuries have been observed. Even a small leakage of the drug may cause a permanent lesion. The most serious injuries were caused by large doses and on the d

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