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Mitomycin-C alone and in combination with infused 5-fluorouracil in the treatment of disseminated gastrointestinal carcinomas

โœ Scribed by Buroker, Thomas R. ;Kim, Paik N. ;Baker, Laurence H. ;Ratanatharathorn, Voravit ;Wojtaszak, Bonnie ;Vaitkevicius, Vainutis K.

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
325 KB
Volume
4
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

One hundred and thirty-two previously untreated patients with metastatic adenocarcinoma of the gastrointestinal (GI) tract were randomized to receive either a 120-hr infusion of 5-fluorouracil (5FU) with mitomycin-C or mitomycin-C alone. Superiority of the combination treatment was demonstrated with remissions in 30 out of 82 (37%) patients versus 9 out of 50 (18%) with the single drug treatment (P = 0.02). The median survial with 5FU--mitomycin-C was 29 weeks, as opposed to 20 weeks with mitomycin-C alone (P = 0.03). The combination produced significantly more severe myelotoxicity than the single drug, and jaundiced patients experienced more myelosuppression than non-jaundiced patients with both treatments.

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Intrahepatic arterial infusion of combin
Intrahepatic arterial infusion of combination of mitomycin-C and 5-fluorouracil in treatment of primary and metastatic liver carcinoma
โœ Dr. N. C. Misra; M. S. D. Jaiswal; R. V. Singh; B. Das ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 392 KB ๐Ÿ‘ 2 views

improvement in drug response and reduction of toxicity were observed after continuous intrahepatic arterial infusion of mytomycin-C (MMC) and 5-fluorouracil (5-FU) in 15 of 26 patients with primary or metastatic carcinoma of the liver. Serum bilirubin values of 10 mg/100 ml absence of ascites, extre