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Mitogen-Independent Phosphorylation of S6K1 and Decreased Ribosomal S6 Phosphorylation in Senescent Human Fibroblasts

โœ Scribed by Hong Zhang; Henry Hoff; Theresa Marinucci; Vincent J. Cristofalo; Christian Sell


Book ID
115603762
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
172 KB
Volume
259
Category
Article
ISSN
0014-4827

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## Abstract Upregulation of the p16 tumor suppressor is a hallmark of senescence in human fibroblasts. In this study, we investigated potential protein modification of p16 in senescent human fibroblasts using 2D SDSโ€“PAGE analysis. Three distinct p16 variants with isoelectric points of 5.2, 5.4, and