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Mitochondrial-Targeting Nitrooxy-doxorubicin: A New Approach To Overcome Drug Resistance

✍ Scribed by Riganti, Chiara; Rolando, Barbara; Kopecka, Joanna; Campia, Ivana; Chegaev, Konstantin; Lazzarato, Loretta; Federico, Antonella; Fruttero, Roberta; Ghigo, Dario

Book ID
120291501
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
576 KB
Volume
10
Category
Article
ISSN
1543-8384

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πŸ“œ SIMILAR VOLUMES

ALPHA-FETOPROTEIN-MEDIATED TARGETINGβ€”A N
ALPHA-FETOPROTEIN-MEDIATED TARGETINGβ€”A NEW STRATEGY TO OVERCOME MULTIDRUG RESISTANCE OF TUMOUR CELLSIN VITRO
✍ ELIZAVETA YU. MOSKALEVA; GALINA A. POSYPANOVA; IGOR I. SHMYREV; ALLA V. RODINA; πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 139 KB

The possibility of overcoming the multidrug resistance of human malignant cells by using doxorubicin conjugated to alpha-fetoprotein (AFP) was studied. It was shown that this type of antitumour drugs, penetrating the cell by receptor-mediated endocytosis with AFP as a vehicle, raises the sensitivity