ALPHA-FETOPROTEIN-MEDIATED TARGETING—A NEW STRATEGY TO OVERCOME MULTIDRUG RESISTANCE OF TUMOUR CELLSIN VITRO
✍ Scribed by ELIZAVETA YU. MOSKALEVA; GALINA A. POSYPANOVA; IGOR I. SHMYREV; ALLA V. RODINA; EKATERINA L. MUIZHNEK; EUGENE S. SEVERIN; VALERY YU. KATUKOV; YURY M. LUZHKOV; SERGEI E. SEVERIN
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 139 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1065-6995
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✦ Synopsis
The possibility of overcoming the multidrug resistance of human malignant cells by using doxorubicin conjugated to alpha-fetoprotein (AFP) was studied. It was shown that this type of antitumour drugs, penetrating the cell by receptor-mediated endocytosis with AFP as a vehicle, raises the sensitivity of the tumour cells that are resistant due to the expression of the multidrug resistance gene mdr1. The sensitivity of antibiotic-resistant cell lines SKVLB (a human ovarian carcinoma) and MCF-7 AdrR (a human breast carcinoma) increased by 10-and 4-fold, respectively, when AFP-conjugated doxorubicin was used. The rationale of using human AFP-antitumour drug conjugates for the development of new chemotherapeutic approaches to cancer treatment is discussed.