𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mitochondrial suppression of a yeast nuclear mutation which affects the translation of the mitochondrial apocytochrome b transcript

✍ Scribed by Gerhard Rödel; Andreas Körte; Fritz Kaudewitz

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
718 KB
Volume
9
Category
Article
ISSN
0172-8083

No coin nor oath required. For personal study only.

✦ Synopsis

We describe a mitochondrial suppressor mutation, which restores respiratory competence to the nuclear pet--mutant MK2. This mutant lacks the message of the mitochondrial cob-gene and instead accumulates a partially spliced pre-mRNA which ,is not translated. Complete processing and translation of the cob-RNA is restored by a rearrangement of the mitochondrial DNA, leading to a fusion of the cob-coding sequences with the leader of olil, the mitochondrial gene coding for subunit IX of the ATPase. We conclude that the nuclear gene affected in MK2 is essential to allow translation of transcripts which contain the cob-leader sequence.

📜 SIMILAR VOLUMES

Mitochondrial and nuclear mutations that
Mitochondrial and nuclear mutations that affect the biogenesis of the mitochondrial ribosomes of yeast
✍ Bolotin-Fukuhara, M. 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 787 KB

We have isolated about five hundred temperature-sensitive mutants specific for the mitochondrial functions. Their growth on glycerol is defective at 36 degrees C and/or 20 degrees C. While most of the mutations were nuclearly inherited, about thirty were found to be of mitochondrial origin. 1) Four

Mitochondrial and nuclear mutations that
Mitochondrial and nuclear mutations that affect the biogenesis of the mitochondrial ribosomes of yeast
✍ Sor, Fr�d�ric ;Faye, G�rard 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 780 KB

1. Several nuclear mutants have been isolated which showed thermo- or cryo-sensitive growth on non-fermentable media. Although the original strain carried mitochondrial drug resistance mutations (CR, ER, OR and PR), the resistance to one or several drugs was suppressed in these mutants. Two of them