๐”– Bobbio Scriptorium
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Mitochondrial sirtuins and metabolic homeostasis

โœ Scribed by Eija Pirinen; Giuseppe Lo Sasso; Johan Auwerx


Book ID
119195176
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
424 KB
Volume
26
Category
Article
ISSN
1521-690X

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The fasting-activated longevity protein sirtuin 1 (SirT1) promotes gluconeogenesis in part, by increasing transcription of the key gluconeogenic genes pepck1 and g6pase, through deacetylating PGC-1โฃ and FOXO1. In contrast, signal transducer and activator of transcription 3 (STAT3) inhibits glucose p