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Mitochondrial permeability transition triggers the release of mtDNA fragments

✍ Scribed by M. Patrushev; V. Kasymov; V. Patrusheva; T. Ushakova; V. Gogvadze; A. Gaziev

Publisher
Springer
Year
2004
Tongue
English
Weight
139 KB
Volume
61
Category
Article
ISSN
1420-682X

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The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observe