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Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

✍ Scribed by Jae-Sung Kim; Lihua He; John J. Lemasters

Book ID
117053767
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
283 KB
Volume
304
Category
Article
ISSN
0006-291X

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✍ Kazuyoshi Kon; Jae-Sung Kim; Hartmut Jaeschke; John J. Lemasters πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 344 KB

Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c