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Mitochondrial Mutations and Hearing Loss: Paradigm for Mitochondrial Genetics

✍ Scribed by Fischel-Ghodsian, N. (author)


Book ID
117852273
Publisher
Cell Press
Year
1998
Tongue
English
Weight
56 KB
Volume
62
Category
Article
ISSN
0002-9297

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Some cases of maternally inherited isolated deafness are caused by mtDNA mutations, frequently following an exposure to aminoglycosides. Two mitochondrial genes have been clearly described as being affected by mutations responsible for this pathology: the ribosomal RNA 12S gene and the transfer RNA