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Mitochondrial dysfunction in neurodegenerative disorders

✍ Scribed by Amy Katherine Reeve, R. N. Lightowlers (auth.), Amy Katherine Reeve, Kim Jennifer Krishnan, Michael R. Duchen, Doug M Turnbull (eds.)


Publisher
Springer-Verlag London
Year
2012
Tongue
English
Leaves
251
Edition
1
Category
Library

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✦ Synopsis


As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

✦ Table of Contents


Front Matter....Pages i-xxi
Front Matter....Pages 1-1
An Introduction to Mitochondria....Pages 3-18
Front Matter....Pages 19-19
Neurodegeneration in Primary Mitochondrial Disorders....Pages 21-41
Mutations in Nuclear Genes That Affect Mitochondrial Function in Parkinson’s Disease....Pages 43-61
Common mtDNA Polymorphisms and Neurodegenerative Disorders....Pages 63-78
mtDNA Mutations in Brain Aging and Neurodegeneration....Pages 79-91
Front Matter....Pages 93-93
Mitochondrial Dysfunction in Neurodegenerative Disease: Protein Aggregation, Autophagy, and Oxidative Stress....Pages 95-111
Mitochondria, Sodium, and Calcium in Neuronal Dysfunction....Pages 113-125
Mitochondrial Membrane Potential and Dynamics....Pages 127-139
Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease....Pages 141-155
Neuronal Mitochondrial Transport and Dysfunction....Pages 157-173
Mitochondrial Changes Associated with Demyelination: Consequences for Axonal Integrity....Pages 175-190
Front Matter....Pages 191-191
Modeling Mitochondrial Dysfunction in Neurodegenerative Disease....Pages 193-212
Front Matter....Pages 213-213
Potential Therapies for Mitochondrial Dysfunction....Pages 215-230
Back Matter....Pages 231-242

✦ Subjects


Neurology; Medical Biochemistry; Neurosciences; Internal Medicine


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