Mitochondrial Dysfunction in Neurodegenerative Disorders

✍ Scribed by Amy K. Reeve, Eve M. Simcox, Michael R. Duchen, Doug M. Turnbull (eds.)

• Publisher: Springer International Publishing
• Year: 2016
• Tongue: English
• Leaves: 379
• Edition: 2
• Category: Library

✦ Synopsis

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.

Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins.

Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

✦ Table of Contents

Front Matter....Pages i-xi
Front Matter....Pages 1-1
An Introduction to Mitochondria, Their Structure and Functions....Pages 3-30
Front Matter....Pages 31-31
Neurodegeneration in Mitochondrial Disorders....Pages 33-58
The Ageing Brain, Mitochondria and Neurodegeneration....Pages 59-80
Mitochondrial Genes and Neurodegenerative Disease....Pages 81-106
Mitochondrial Signaling and Neurodegeneration....Pages 107-137
Front Matter....Pages 139-139
Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson’s Disease....Pages 141-173
Mitochondrial Dynamics and Neurodegeneration....Pages 175-191
Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation....Pages 193-217
Mitochondria, the Synapse, and Neurodegeneration....Pages 219-239
Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration....Pages 241-253
Mitochondrial Degradation, Autophagy and Neurodegenerative Disease....Pages 255-278
The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria....Pages 279-300
Front Matter....Pages 301-301
Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?....Pages 303-328
Mitochondrial Function and Dynamics Imaged In Vivo....Pages 329-345
Front Matter....Pages 347-347
Development of Treatments and Therapies to Target Mitochondrial Dysfunction....Pages 349-371
Summary and Conclusions....Pages 373-376
Back Matter....Pages 377-380

✦ Subjects

Neurology; Medical Biochemistry; Neurosciences; Internal Medicine