✦ LIBER ✦

Mitochondrial dysfunction and neuromuscular disease

✍ Scribed by Rachel A. Nardin; Donald R. Johns

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 336 KB
Volume: 24
Category: Article
ISSN: 0148-639X
DOI: 10.1002/1097-4598(200102)24:2<170::aid-mus30>3.0.co;2-0

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✦ Synopsis

Mitochondrial diseases are a heterogeneous group of disorders with widely varying clinical features, due to defects in mitochondrial function. Involvement of both muscle and nerve is common in mitochondrial disease. In some cases, this involvement is subclinical or a minor part of a multisystem disorder, but myopathy and neuropathy are a major, often presenting, feature of a number of mitochondrial syndromes. In addition, mitochondrial dysfunction may play a role in a number of classic neuromuscular diseases. This article reviews the role of mitochondrial dysfunction in neuromuscular disease and discusses a rational approach to diagnosis and treatment of patients presenting with a neuromuscular syndrome due to mitochondrial disease.

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