Mitochondrial DNA Alterations in Cancer
β Scribed by Copeland, William C.; Wachsman, Joseph T.; Johnson, F. M.; Penta, John S.
- Book ID
- 121185379
- Publisher
- Informa plc
- Year
- 2002
- Tongue
- English
- Weight
- 194 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0735-7907
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## Abstract ## Background Alterations in mitochondrial DNA have been identified in a number of solid tumor types, including gastric, head and neck, breast, colorectal, lung, and bladder carcinomas. Recently, a homopolymeric C stretch (D310) located within the noncoding Dβloop of the mitochondrial
It has been reported that various cancers frequently have mutations in the D-loop region of mitochondrial DNA (mtDNA). We examined the genetic alterations in this region of esophageal cancer using direct sequencing. Of 68 sequence variants, 15 have not been reported to date. Tumor mtDNA with these v
Articles In The Fields Of Biochemistry And Physiology, Cell Biology, Developmental Biology, Ecology, Evolution, Genetics, Immunology, Molecular Biology, Neuroscience, Microbiology And Virology, Plant Science, Structural Biology, Science And Society. Includes Index.