✦ LIBER ✦

Mitochondrial DNA alteration in esophageal cancer

✍ Scribed by Kenji Hibi; Hiroshi Nakayama; Taiji Yamazaki; Tsunenobu Takase; Masumi Taguchi; Yasushi Kasai; Katsuki Ito; Seiji Akiyama; Akimasa Nakao

Publisher: John Wiley and Sons
Year: 2001
Tongue: French
Weight: 71 KB
Volume: 92
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.1204

No coin nor oath required. For personal study only.

✦ Synopsis

It has been reported that various cancers frequently have mutations in the D-loop region of mitochondrial DNA (mtDNA). We examined the genetic alterations in this region of esophageal cancer using direct sequencing. Of 68 sequence variants, 15 have not been reported to date. Tumor mtDNA with these variants were compared with mtDNA from corresponding normal esophageal mucosa. Two of 37 primary esophageal cancers (5%) contained somatic mutations in the D-loop region of mtDNA. Although the mutation rate of mitochondrial tumor DNA within the D-loop was not high, this result suggested that mtDNA mutations play a role in the development of esophageal cancer.

📜 SIMILAR VOLUMES

Mitochondrial DNA Alterations in Cancer

✍ William C. Copeland; Joseph T. Wachsman; F. M. Johnson; John S. Penta 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 49 KB 👁 1 views

Mitochondrial DNA alterations in thyroid

Mitochondrial DNA alterations in thyroid cancer

✍ Betty C. Tong; Patrick K. Ha; Karan Dhir; Mingzhao Xing; William H. Westra; Davi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB 👁 1 views

## Abstract ## Background Alterations in mitochondrial DNA have been identified in a number of solid tumor types, including gastric, head and neck, breast, colorectal, lung, and bladder carcinomas. Recently, a homopolymeric C stretch (D310) located within the noncoding D‐loop of the mitochondrial

Alteration of mitochondrial DNA in human

Alteration of mitochondrial DNA in human oncocytomas

✍ Cornelius Welter; Gyula Kovacs; Gerhard Seitz; Dr. Nikolaus Blin 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

Oncocytoma, a benign solid tumor, occurs in a number of organs but most frequently in the kidneys. Its oncocytes display an intensely eosinophilic cytoplasm due to presence of numerous mitochondria. Mitochondrial DNA analysis of six renal cell oncocytomas and adjacent renal tissue was performed usin

Mitochondrial DNA mutations and mitochon

Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer

✍ Chew-Wun Wu; Pen-Hui Yin; Wen-Yi Hung; Anna Fen-Yau Li; Shu-Hui Li; Chin-Wen Chi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 308 KB 👁 1 views

## Abstract Gastric carcinoma is one of the most common types of cancer in Taiwan. Somatic mitochondrial DNA (mtDNA) alteration in gastric carcinoma and its association with clinicopathologic features remain unclear. When we used polymerase chain reaction (PCR) and direct sequencing, 15 of the 31 (

Mitochondrial DNA mutations and mitochon

Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer

✍ Ling-Ming Tseng; Pen-Hui Yin; Chin-Wen Chi; Chih-Yi Hsu; Chew-Wun Wu; Liang-Ming 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract Somatic mutations in mitochondrial DNA (mtDNA) have been demonstrated in various tumors, including breast cancer. However, it still remains unclear whether the alterations in mtDNA are related to the clinicopathological features and/or the prognosis in the breast cancer. We analyzed som

Frequent somatic mutations of mitochondr

Frequent somatic mutations of mitochondrial DNA in esophageal squamous cell carcinoma

✍ Hiroshi Kumimoto; Yoshihiro Yamane; Yoshio Nishimoto; Hiroko Fukami; Masayuki Sh 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 70 KB

## Abstract Recent studies of various cancers, such as those of the breast, head and neck, bladder and lung, reported that 46–64% of somatic mutations in the D‐loop region of mitochondrial DNA (mtDNA) are observed. However, in esophageal cancer, only a low rate (5%) of somatic mutations has so far