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Mitochondrial ATP-independent chaperones

✍ Scribed by Nikos Petrakis; Felicity Alcock; Kostas Tokatlidis

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 202 KB
Volume: 61
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.235

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✦ Synopsis

Abstract

Mitochondria possess a dedicated‐chaperone system in the intermembrane space, the small Tims that are ubiquitous in all eukaryotes from yeast to man. They escort membrane proteins to the outer or the inner membrane for proper insertion. These mitochondrial chaperones do not require external energy to perform their function and have structural similarities to other ATP‐independent chaperones. Here, we discuss their structural properties and how these relate to their chaperoning function in the mitochondrial intermembrane space. © 2009 IUBMB IUBMB Life 61(9): 909–914, 2009

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