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Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis

✍ Scribed by Yasunori Ichiki; Carlo Selmi; Shinji Shimoda; Hiromi Ishibashi; Stuart C. Gordon; M. Eric Gershwin


Book ID
111637198
Publisher
Humana Press Inc
Year
2005
Tongue
English
Weight
248 KB
Volume
28
Category
Article
ISSN
1080-0549

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The appearance of autoantibodies against mitochondria in patients with primary biliary cirrhosis has been known for more than 25 yr. In the past, based on the biochemical complexity of the mitochondrion and the use of crude extracts for immunodiagnosis, a degree of nonspecificity in assaying for ant