Mismatch repair gene mutations and cancer risks: an update
β Scribed by AK Win; JL Hopper; MA Jenkins; Australasian Colorectal Cancer Family Study and the Colon Cancer Family Registry
- Book ID
- 115027777
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 68 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1897-4287
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Excessive incidence of various cancers is a challenging feature of the hereditary-non-polyposis-colorectal-cancer (HNPCC) syndrome. This study estimated the cancer incidences in HNPCC compared with the general population. Individuals in a cohort of 1763 members of 50 genetically diagnosed families w
Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant disease caused by germline mutations in DNA mismatch repair genes. The mutational spectrum in these genes appears to be diverse, in both the distribution and the nature of the mutations. However, most described mutation