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Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines

✍ Scribed by Susanne Seitz; Peter Waβmuth; Jens Plaschke; Hans K. Schackert; Uwe Karsten; Mauro-F. Santibanez-Koref; Peter M. Schlag; Siegfried Scherneck

Book ID
111700311
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
192 KB
Volume
37
Category
Article
ISSN
1045-2257

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Microsatellite instability (MSI) caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome but is also found in about 15% of all sporadic tumors. Most affected microsatellites reside in untranslated inter