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Mismatch repair defective breast cancer in the hereditary nonpolyposis colorectal cancer syndrome

✍ Scribed by Uffe Birk Jensen; Lone Sunde; Susanne Timshel; Britta Halvarsson; Anja Nissen; Inge Bernstein; Mef Nilbert


Publisher
Springer US
Year
2009
Tongue
English
Weight
410 KB
Volume
120
Category
Article
ISSN
0167-6806

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Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant disease caused by germline mutations in DNA mismatch repair genes. The mutational spectrum in these genes appears to be diverse, in both the distribution and the nature of the mutations. However, most described mutation