Mismatch repair defective breast cancer in the hereditary nonpolyposis colorectal cancer syndrome
β Scribed by Uffe Birk Jensen; Lone Sunde; Susanne Timshel; Britta Halvarsson; Anja Nissen; Inge Bernstein; Mef Nilbert
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 410 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The
Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant disease caused by germline mutations in DNA mismatch repair genes. The mutational spectrum in these genes appears to be diverse, in both the distribution and the nature of the mutations. However, most described mutation