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Mirthful laughter induced by subthalamic nucleus stimulation

✍ Scribed by Paul Krack; Rajeev Kumar; Claire Ardouin; Patricia Limousin Dowsey; John M. McVicker; Alim-Louis Benabid; Pierre Pollak

Book ID
102501118
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
445 KB
Volume
16
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

High‐frequency stimulation of the subthalamic nucleus (STN) improves the motor signs of Parkinson's disease (PD). The three main components (motor, associative, and limbic) of the cortical‐basal ganglia‐cortical circuits pass through the STN. It is not known whether STN stimulation can influence the limbic loop. We present two PD patients in whom acute stimulation of an electrode located in the STN using high stimulation parameters (50% higher than therapeutic) induced funny associations, leading to infectious laughter and hilarity, whereas the therapeutic parameters induced a hypomanic behavior and marked improvement of akinesia. Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation. © 2001 Movement Disorder Society.

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