✦ LIBER ✦

Mirex induces ornithine decarboxylase in female rat liver

✍ Scribed by Mitra, Ashoke ;Richards, Ira ;Kitchin, Kirk ;Conolly, Rory ;Kulkarni, Arun P.

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 524 KB
Volume: 5
Category: Article
ISSN: 0887-2082
DOI: 10.1002/jbt.2570050207

No coin nor oath required. For personal study only.

✦ Synopsis

Ornithine decarboxylase, the rate-limiting enzyme in polyamine synthesis, was significantly induced in female rat liver following oral administration of the pesticide mirex. After dual oral exposure (120 mg /kg of mirex; 21 and 4 hr prior to sacrifice), ornithine decarboxylae activity in rat liver cytosol was 70-fold higher than control values. A single oral dose of mirex (180 mg /kg) induced hepatic ornithine decarboxylase activity 55-fold over controls. After a single oral dose of mirex the maximal induction of ODC activity occurred at 36 hr. Mirex is an unusually potent and long-lasting inducer of rat hepatic ornithine decarboxylase activity.

📜 SIMILAR VOLUMES

Allylisopropylacetamide induces rat hepa

Allylisopropylacetamide induces rat hepatic ornithine decarboxylase

✍ Kitchin, Kirk T. ;Brown, Janice L. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB

In rat liver, allylisopropylacetamide (AIA) treatment strongly induced (25-fold) the activity of rat hepatic ornithine decarboxylase (ODC). By either the oral or the subcutaneous route, AIA produced a long-lasting induction (30 to 40 hours) of hepatic ODC activity. Three analogs of AIA, propylisopro

Ornithine decarboxylase and ornithine de

Ornithine decarboxylase and ornithine decarboxylase-inhibiting activity in rat thymocytes

✍ Dr Claudio Stefanelli; Carmen Rossoni; Fabrizia Ferrari; Flavio Flamigni; Claudi 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 627 KB

Mirex-induced adaptive liver growth in r

Mirex-induced adaptive liver growth in rats subjected to thyroidectomy

✍ James D. Yarbrough; Jo M. Grimley; Jaideep V. Thottassery 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 565 KB

The organochlorine compound mirex (dodecachlorooctahydro-1,3,4-metheno-2H-cyclobuta-CD-pentalene) induces an adaptive liver growth dependent on the hormonal status of the experimental animal. In the intact laboratory rat, mirex induces liver growth that is an expression of both cellular hyperplasia

Induction of an ornithine decarboxylase-

Induction of an ornithine decarboxylase-antizyme in chicken liver

✍ M.A. Grillo; S. Bedino; G. Testore 📂 Article 📅 1980 🏛 Elsevier Science 🌐 English ⚖ 572 KB

Ornithine decarboxylation in rat liver n

Ornithine decarboxylation in rat liver nuclei

✍ M.A. Grillo; T. Fossa 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 253 KB

Consequences of aberrant ornithine decar

Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells

✍ Margaret E. Tome; Steven M. Fiser; Eugene W. Gerner 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 757 KB

Arizona 85724 DH23A cells, an a-difluoromethylornithine (DFMO)-resistant variant of rat hepatoma tissue culture cells (HTC), contain high levels of very stable ornithine decarboxylase (ODC). In the absence of DFMO, the high ODC activity results in a large accumulation of endogenous putrescine. Conco