Allylisopropylacetamide induces rat hepatic ornithine decarboxylase

✍ Scribed by Kitchin, Kirk T. ;Brown, Janice L.

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 452 KB
• Volume: 2
• Category: Article
• ISSN: 0887-2082
• DOI: 10.1002/jbt.2570020306

✦ Synopsis

In rat liver, allylisopropylacetamide (AIA) treatment strongly induced (25-fold) the activity of rat hepatic ornithine decarboxylase (ODC). By either the oral or the subcutaneous route, AIA produced a long-lasting induction (30 to 40 hours) of hepatic ODC activity. Three analogs of AIA, propylisopropylacetamide (PIA), allobarbital, and allylbenzene, were active ODC inducers while a fourth, allylacetate, was not. Although induction of hepatic aminolevulinic acid (ALA) synthetase activity and the accumulation of hepatic porphyrins depend on the ally1 moiety of AIA, this is not the case with hepatic ODC i n d u c t i o n . Allylisopropylacetamide d i d not elevate s e r u m a l a n i n e aminotransferase (SGPT) nor did it cause DNA damage, as measured by the alkaline elution assay. Thus, hepatic cell death is not a likely explanation of AIA's long-lasting induction of ODC. As AIA does not belong to any of the common categories of ODC inducers, it may be the chemical prototype of a new class of hepatic ODC inducers.