𝔖 Bobbio Scriptorium
✦   LIBER   ✦

“Mir”acles in hox gene regulation

✍ Scribed by Vivek S. Chopra; Rakesh K. Mishra

Book ID
101708863
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
140 KB
Volume
28
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Micro RNAs (miRNAs) have been shown to control many cellular processes including developmental timing in different organisms. The prediction that miRNAs are involved in regulating hox genes of flies and mouse is quite a recent idea and is supported by the finding that mir‐196 represses Hoxb8 gene expression. The non‐coding regions that encode these miRNAs are also conserved across species in the same way as other mechanisms that regulate expression of hox genes. On the contrary, until now no homeotic phenotype, a hallmark of any hox gene mutation, had been associated with any hox miRNA. Recent work on bithorax complex miRNA (miR–iab‐4–5p) shows, for the first time, that miRNAs can lead to homeotic transformation. This miRNA regulates Ultrabithorax (Ubx) and results in the transformation of haltere to wing.1 This study unveils a new complexity and finesse to the regulation of hox gene expression pattern that is needed for determining the anteroposterior body axis in all bilaterians. BioEssays 28: 445–448, 2006. © 2006 Wiley Periodicals, Inc.

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