𝔖 Bobbio Scriptorium
✦   LIBER   ✦

How does noncoding transcription regulate Hox genes?

✍ Scribed by Adelheid Lempradl; Leonie Ringrose

Book ID
101711511
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
319 KB
Volume
30
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Noncoding RNA has arrived at centre stage in recent years with the discovery of "hidden transcriptomes" in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies1-3 have examined the role of these noncoding RNAs in Hox gene regulation, and have generated a fierce debate as to whether the noncoding transcripts are important for silencing or activation. Here we review the evidence, and show that, by taking developmental timing into account, some of these apparently conflicting results can be resolved. We examine current models that explain these data and explore alternative interpretations.

📜 SIMILAR VOLUMES

HOX gene network is involved in the tran
HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis
✍ Monica Cantile; Alfredo Procino; Maria D'armiento; Luca Cindolo; Clemente Cillo 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 402 KB 👁 1 views

## Abstract Adipogenesis is regulated by the sequential activation of a series of transcription factors: the C/EBP proteins of type β and δ trigger the process while PPARγ and C/EBPα induce the differentiation from pre‐adipocyte to adipocyte, followed by adipo‐specific gene expression. A number of