Molecular studies have revealed that microsatellite instability and loss of heterozygosity occurred in head-and-neck cancer, suggesting the involvement both of suppressor and of mutator pathways in head-and-neck carcinogenesis. There is evidence for relations between tumor phenotype and clinical par
Mir-148a Improves Response to Chemotherapy in Sensitive and Resistant Oesophageal Adenocarcinoma and Squamous Cell Carcinoma Cells
β Scribed by Richard Hummel; David I. Watson; Cameron Smith; Jakob Kist; Michael Z. Michael; Joerg Haier; Damian J. Hussey
- Book ID
- 107412089
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 369 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1091-255X
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## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##
Glutathione S-transferases (GSTs) are metabolic phase II enzymes that promote reactive metabolite elimination by conjugating them to glutathione (GSH). Because of their important role in xenobiotic metabolism and detoxification, they have been implicated in carcinogenesis processes, especially epith