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MiR-125b targets BCL3 and suppresses ovarian cancer proliferation

✍ Scribed by Yi Guan; Hailan Yao; Zhihong Zheng; Guangrong Qiu; Kailai Sun

Book ID
102865259
Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
796 KB
Volume
128
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Micro‐RNAs (miRNAs) important for post‐transcriptional gene expression as negative regulators are endogenous 21‐ to 23‐nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR‐125b was underexpressed in human OC specimens. Ectopic expression of miR‐125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal formation. This inhibitory effect on OC cell growth was mediated by miR‐125b inhibition of the translation of an mRNA encoding a proto‐oncogene, BCL3. Furthermore, expression of miR‐125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR‐125b may contribute to OC development.

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