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Minor-groove width and accessibility in B-DNA drug and protein complexes

✍ Scribed by Stephen Neidle


Book ID
115925730
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
360 KB
Volume
298
Category
Article
ISSN
0014-5793

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The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit