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DNA Accessibility to Minor Groove Ligands in Core Nucleosome and Chromatosome

โœ Scribed by Fodera, R.; Caneva, R.; Canzonetta, C.; Savino, M.


Book ID
121190875
Publisher
Taylor and Francis Group
Year
2000
Tongue
English
Weight
525 KB
Volume
19
Category
Article
ISSN
0732-8311

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The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit