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Minimization of Fragmentation and Aggregation by Laser Desorption Laser Ionization Mass Spectrometry

✍ Scribed by Wu, Qinghao; Pomerantz, Andrew E.; Mullins, Oliver C.; Zare, Richard N.


Book ID
120633541
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
360 KB
Volume
24
Category
Article
ISSN
1044-0305

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Oligonucleotide sequencing by fragmentation in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry has been demonstrated. With this sequencing method, the preparation of oligonucleotide ladder products and gel electrophoresis are not required, thus the sequencing