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Minimising the potential for metabolic activation in drug discovery

✍ Scribed by Kalgutkar, Amit S; Soglia, John R

Book ID
111869585
Publisher
Informa plc
Year
2005
Tongue
English
Weight
738 KB
Volume
1
Category
Article
ISSN
1742-5255

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## Abstract Metabolic activation of drug candidates to electrophilic reactive metabolites that can covalently modify cellular macromolecules may result in acute and/or idiosyncratic immune system‐mediated toxicities in humans. This presents a significant potential liability for the future developme