## Abstract Complex genetic traits are inherently heterogeneous, i.e., they may be caused by different genes, or nonβgenetic factors, in different individuals. So, for mapping genes responsible for these diseases using linkage analysis, heterogeneity must be accounted for in the model. Heterogeneit
Minimax Hierarchical Empirical Bayes Estimation in Multivariate Regression
β Scribed by Samuel D. Oman
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 171 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0047-259X
No coin nor oath required. For personal study only.
β¦ Synopsis
The multivariate normal regression model, in which a vector y of responses is to be predicted by a vector x of explanatory variables, is considered. A hierarchical framework is used to express prior information on both x and y. An empirical Bayes estimator is developed which shrinks the maximum likelihood estimator of the matrix of regression coefficients across rows and columns to nontrivial subspaces which reflect both types of prior information. The estimator is shown to be minimax and is applied to a set of chemometrics data for which it reduces the crossvalidated predicted mean squared error of the maximum likelihood estimator by 380.
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