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MINIMAL SIDE-CHAIN PROTECTION CAN BE A SUCCESSFUL STRATEGY IN SOLID-PHASE PEPTIDE SYNTHESIS

✍ Scribed by COY, DAVID H. ;BRANYAS, NANCY


Book ID
115097552
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
339 KB
Volume
14
Category
Article
ISSN
0367-8377

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## Abstract The sequence‐dependent, acid‐ or base‐catalysed aspartimide formation is one of the most serious side reactions in solid‐phase synthesis of peptides containing aspartic acid. In the present work, we investigated the susceptibility of 4‐{__N__‐[1‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐3