## Abstract CD4^+^ T cell help during the priming of CD8^+^ T lymphocytes imprints the capacity for optimal secondary expansion upon reβencounter with antigen. Helped memory CD8^+^ T cells rapidly expand in response to a secondary antigen exposure, even in the absence of T cell help and, are most e
Mini-review CD4 T cells are required for CD8 T cell memory generation
β Scribed by Christine Bourgeois; Corinne Tanchot
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 94 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0014-2980
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Mechanisms controlling the Th1/Th2 phenotype of a primary immune response are often discussed assuming that the generation of Th1 and Th2 cells from the common CD4 + precursor T helper (pTh) involves an interaction of this pTh cell with an antigen-presenting cell (APC) in the form of a two-cell inte
Efficient protocols to generate cytomegalovirus (CMV)-specific T cells are required for adoptive immunotherapy. Recombinant Epstein-Barr virus (EBV) vectors called mini-EBV can be used to establish permanent B cell lines in a single step, which present the CMV antigen pp65 in a constitutive manner.