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Mimosine Differentially Inhibits DNA Replication and Cell Cycle Progression in Somatic Cells Compared to Embryonic Cells of Xenopus laevis

✍ Scribed by Y. Wang; J. Zhao; J. Clapper; L.D. Martin; C. Du; E.R. DeVore; K. Harkins; D.L. Dobbs; R.M. Benbow


Book ID
115601964
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
561 KB
Volume
217
Category
Article
ISSN
0014-4827

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## Abstract We have recently found that aphidicolin, a tetracyclic diterpene‐tetraol produced by several fungi, blocks DNA synthesis of sea urchin embryos by interfering with the activity of DNA polymerase Ξ±. These cells fail to proliferate in the presence of aphidicolin. In continuation of these