Milonine, an 8,14-dihydromorphinandienone alkaloid from leaves of Cissampelos sympodialis

Characterization of an extract from the

Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea

✍ George Thomas; Fiona Burns; Susan Pyne; Nigel J. Pyne 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 57 KB 👁 2 views

An aqueous fraction of the ethanol extract of the leaves (AFL) of Cissampelos sympodialis Eichl. (Menispermaceae) was shown to relax the spontaneous tone of guinea-pig tracheal smooth muscle rings with an IC 50 of 20.5 g/mL. The AFL inhibited cyclic nucleotide phosphodiesterase activity in isolated