✦ LIBER ✦

Milestones in Huntington disease

✍ Scribed by Ira Shoulson; Anne B. Young

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 109 KB
Volume: 26
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.23685

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done before we have a full understanding of the pathophysiology of the disease. Clinical research on biomarkers and clinical trials on potential neuroprotective agents are underway. Here we review our progress in these areas over the last 25 years and speculate on what the next 25 years may hold. © 2011 Movement Disorder Society

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