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Mild and efficient synthesis of aryliodonium ylides of 2,6-dimethylpyrimidin-4-ol

✍ Scribed by Ravi Kumar; Reshmi R. Nair; Om Prakash


Book ID
102233758
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
151 KB
Volume
21
Category
Article
ISSN
1042-7163

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✦ Synopsis


Abstract

Mild and efficient synthesis of new synthetically useful aryliodonium ylides of 2,6‐dimethyl‐ pyrimidin‐4‐ol (3a–d) using (dichloroiodo)arenes in aqueous medium is reported. Antibacterial activity of these ylides 3a–d against Escherichia coli and Bacillus Licheniformis is also described. Β© 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:339–342, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20608


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Synthesis of a series of new 4-substituted-3-aryl-1-(2,6-dimethylpyrimidin-4-yl)pyrazoles (2a-g, 3ag, and 4a-g) is described. All the synthesized compounds were evaluated in vitro for their antibacterial activity against two gram-positive and two gram-negative bacteria, namely, Bacillus subtilis (MT