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Mild and effective cleavage of esters with bis(tributyltin) oxide: A useful application in the deprotection of Pom penicillanate esters

โœ Scribed by Ernesto G Mata; Oreste A Mascaretti


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
259 KB
Volume
29
Category
Article
ISSN
0040-4039

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Bis (tributyltin) oxide. A mild, neutral
โœ Claudio J. Salomon; Ernesto G. Mata; Oreste A. Mascaretti ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 309 KB

Bis(tributyltin)oxide acts as a mild, neutral and chemoselective ester cleavage reagent for a variety of carboxylic esters with good to excellent yields. The acyl-oxygen cleavage mechanism of (-)-(1 R) menthyl acetate is discussed.