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Mikrobiologische Hydroxylierungen von Cortexon in der 7α-, 15α- oder 15β-Stellung. Mikrobiologische Reaktionen, 5. Mitteilung

✍ Scribed by Ch. Meystre; E. Vischer; A. Wettstein

Publisher: John Wiley and Sons
Year: 1955
Tongue: German
Weight: 950 KB
Volume: 38
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19550380202

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✦ Synopsis

Abstract

In continuation of our earlier work certain fungi were detected which are capable of hydroxylating steroids at further carbon atoms of the nucleus. These microbiological procedures have made possible the preparation of new cortexone derivatives with an additional hydroxyl group in 7α‐, 15α‐ or 15β‐position. The elucidation of the constitution of these compounds by degradation and chemical connection with known steroids has been accomplished. From the molecular rotation differences observed the configuration of 2α, 3β, 15α‐trihydroxy‐5α, 22 a‐spirostane is suggested for digitogenin.

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Mikrobiologische Hydroxylierung von Steroiden in der 17α- und 21-Stellung. Mikrobiologische Reaktionen, 4. Mitteilung

✍ Ch. Meystre; E. Vischer; A. Wettstein 📂 Article 📅 1954 🏛 John Wiley and Sons 🌐 German ⚖ 429 KB

## Abstract Some fungi, especially strains of the genus Trichothecium were found to be able of introducing a hydroxy group into the 17 α‐position of the steroid molecule. By means of this microbiological process, cortexone was converted into 17 α‐hydroxy‐cortexone (__Reichstein's__ substance S), 11