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Mikrobiologische Hydroxylierung von Steroiden in der 17α- und 21-Stellung. Mikrobiologische Reaktionen, 4. Mitteilung

✍ Scribed by Ch. Meystre; E. Vischer; A. Wettstein

Publisher: John Wiley and Sons
Year: 1954
Tongue: German
Weight: 429 KB
Volume: 37
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19540370523

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✦ Synopsis

Abstract

Some fungi, especially strains of the genus Trichothecium were found to be able of introducing a hydroxy group into the 17 α‐position of the steroid molecule. By means of this microbiological process, cortexone was converted into 17 α‐hydroxy‐cortexone (Reichstein's substance S), 11‐dehydro‐corticosterone into cortisone, and finally corticosterone into 17 α‐hydroxy‐corticosterone (hydrocortisone) and cortisone.

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Mikrobiologische Hydroxylierungen von Cortexon in der 7α-, 15α- oder 15β-Stellung. Mikrobiologische Reaktionen, 5. Mitteilung

✍ Ch. Meystre; E. Vischer; A. Wettstein 📂 Article 📅 1955 🏛 John Wiley and Sons 🌐 German ⚖ 950 KB

## Abstract In continuation of our earlier work certain fungi were detected which are capable of hydroxylating steroids at further carbon atoms of the nucleus. These microbiological procedures have made possible the preparation of new cortexone derivatives with an additional hydroxyl group in 7α‐,