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Microwave-Promoted Aromatization of 1,3,5-Trisubstituted 4,5-Dihydro-1H-pyrazoles by Calcium Hypochlorite under Solvent-Free Conditions.

โœ Scribed by Davood Azarifar; Azadeh Gharshasbi


Publisher
John Wiley and Sons
Year
2006
Weight
18 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract magnified image An efficient microwaveโ€assisted synthesis of 1โ€carboxymethylโ€5โ€trifluoromethylโ€5โ€hydroxyโ€4,5โ€dihydroโ€1__H__โ€pyrazoles from the cyclocondensation reaction between enones [CF~3~C(O)C(R^2^) = C(R^1^)(OR), where R^2^ = H, Me; R^1^ = H, Me, Et, Pr, __i__โ€Pr, __t__โ€Bu, __i__โ€B

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A simple method for the synthesis of 2-pyrazolines is described which occurs on silica surface under solvent-free conditions within 110-180 sec using microwave irradiation. The results obtained indicate that the use of silica gel as a support in pyrazoline formation reactions can have a profound eff