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Microwave-induced perchloric acid catalyzed novel solvent-free synthesis of 4-aryl-3,4-dihydropyrimidones via biginelli condensation

✍ Scribed by Chhanda Mukhopadhyay; Arup Datta; Bimal K. Banik

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
172 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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We report here domestic microwave‐induced perchloric acid‐catalyzed solvent‐free synthesis of various 4‐aryl‐3,4‐dihydropyrimidones for the first time. In all the cases the yields are excellent and the mechanism follows a simple Biginelli condensation to produce the dihydropyrimidones in a few seconds. This procedure has been successfully employed to synthesize the mitotic kinesin EG5 inhibitor Monastrol (Figure I).

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